Set in a slightly futuristic world where Earth has been invaded and is at war with aliens from another dimension called the Nova, the story follows the adventures of a Japanese boy named Kazuya Aoi who enrolls for training at a special school for genetically modified girls called Pandoras who battle the aliens, and their male partners, called Limiters, who use a special power called "freezing" to limit their opponent's mobility. The protagonist makes the acquaintance of an unusual older girl named Bridgette L. Satellizer who appears to be the most powerful Pandora in her class, but has not yet chosen a male partner to be her Limiter, and in spite of the warnings of all his friends, he decides to be her Limiter.
Beings from a different dimension have started a war with mankind. To counter this threat, an academy called "Genetics" that trains female warriors called "Pandora," who can wield special weaponry and armor, was formed. Kazuya Aoi decided to enroll in this school because of a promise with his sister, an outstanding alumnus who died in battle. There he meets second year Bridgette L. Satellizer, nicknamed "The Untouchable Queen" due to her solitary demeanor but also top of her class whose battle simulation streak is undefeated, until he came... and slowly changed her.